Handwritten letter to Jim Wiggins regarding an autograph request. Written and signed "E.B. Chain" in fountain pen ink. Folding creases, otherwise, in very good condition. (1906-1979) Sir Ernst Boris Chain was a German-born British biochemist best known for being a co-recipient of the Nobel Prize in Physiology or Medicine for his work on penicillin.In 1939, he joined Howard Florey to investigate natural antibacterial agents produced by microorganisms. This led him and Florey to revisit the work of Alexander Fleming, who had described penicillin nine years earlier. Chain and Florey went on to discover penicillin's therapeutic action and its chemical composition. Chain and Florey discovered how to isolate and concentrate the germ-killing agent in penicillin. For this research, Chain, Florey, and Fleming received the Nobel Prize in 1945.Along with Edward Abraham he was also involved in theorizing the beta-lactam structure of penicillin in 1942, which was confirmed by X-ray crystallography done by Dorothy Hodgkin in 1945. Towards the end of World War II, Chain learned his mother and sister had been killed by the Nazis. After World War II, Chain moved to Rome, to work at the Istituto Superiore di Sanità (Superior Institute of Health). He returned to Britain in 1964 as the founder and head of the biochemistry department at Imperial College London, where he stayed until his retirement, specializing in fermentation technologies.On 17 March 1948 Chain was appointed a Fellow of the Royal Society.In 1948, he married Anne Beloff, sister of Renee Beloff, Max Beloff, John Beloff and Nora Beloff, and a biochemist of significant standing herself. In his later life, his Jewish identity became increasingly important to him. Chain was an ardent Zionist and he became a member of the board of governors of the Weizmann Institute of Science at Rehovot in 1954, and later a member of the executive council. He raised his children securely within the Jewish faith, arranging much extracurricular tuition for them. His views were expressed most clearly in his speech 'Why I am a Jew' given at the World Jewish Congress Conference of Intellectuals in 1965.Chain was appointed Knight Bachelor in the 1969 Birthday Honours.This lot came from the Jim Wiggins collection we purchased in July 2022. Jim Wiggins accumulated the most unique and valuable autograph collection over a period of 70-plus years. He obtained his collection either in person or by writing to persons of fame and notoriety. Comes with a full Letter of Authenticity from Todd Mueller Authentics.