Queen of Castile from 1474 until her death in 1504, reigning over a dynastically unified Spain together with her husband, King Ferdinand II of Aragon; they are best remembered for establishing the Spanish Inquisition and for financing Christopher Columbus's 1492 voyage that led to the discovery of the New World . Manuscript DS in Spanish, signed “Yo la Reyna,” one page, 8 x 9.75, June 30, 1502. Royal decree ordering her chamberlain Sancho de Paredes to pay 200 ducats to Diego de Ribera, chamberlain of the Princess of Castile, so that he may give them to Gaspar de Payna, a servant of the king of Portugal, for gifts brought from her grandson, the prince of Portugal. Attractively double-matted and framed with a portrait and caption to an overall size of 20.75 x 16.75. In fine condition. An especially clean, attractive example of an Isabella document.