Darwin, Charles. On the Origin of Species by Means of Natural Selection. London: John Murray, 1860. Fifth Thousand (2nd ed., 2nd issue.) 8vo. ix, [1], 502, 32 ads pp. + folding diagram. Modern full calf with boards in blind, title on label in gilt, gilt devices in compartments, top edge gilt. Early ink signature to title, prelims and first 46 pages with tissue reinforcement along front margin, quite clean overall though with a few pencil notes and light foxing to a few leaves, one leaf with a 1" closed tear, Very Good. **************************** An early issue of Darwin's important work. The 1250 copies of the first edition of 1859 were sold out almost immediately and a reprint the same year met with the same result. The second edition, identified "Fifth Thousand" on the title page, included some corrections and changes by Darwin. [Freeman 376]