200-146 BC Roman Carthage Ancient Grades vf. As the dominant power of the western Mediterranean, Carthage inevitably came into conflict with many neighbours and rivals, from the Berbers of North Africa to the nascent Roman Republic. Following centuries of conflict with the Sicilian Greeks, its growing competition with Rome culminated in the Punic Wars (264–146 BCE), which saw some of the largest and most sophisticated battles in antiquity. Carthage narrowly avoided destruction after the Second Punic War, but was destroyed by the Romans in 146 BC after the Third Punic War. The Romans later founded a new city in its place. All remnants of Carthaginian civilization came under Roman rule by the first century AD, and Rome subsequently became the dominant Mediterranean power, paving the way for its rise as a major empire.